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NIH-funded researchers link epigenome changes to Alzheimer’s disease

Two new NIH-supported studies have shown that a person’s epigenome—the chemical modifications, or marks, on our DNA that turn gene activity on and off—may influence Alzheimer’s disease-related changes in the brain.  The two groups of researchers examined brain tissue donated by volunteers with Alzheimer’s and those free of the disease and linked a specific epigenome marker, DNA methylation, with Alzheimer’s pathology in the brain.

Blog post - Funding opportunity for research on chronic inflammation

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Chronic inflammation increases with aging, and it is linked to heart disease, diabetes, dementia, and cancer, as well as frailty and disability. The NIA is offering new funding for research on chronic inflammation. If you study inflammation, please read about this grant opportunity and consider applying.

Physical activity and Alzheimer’s-related hippocampal atrophy

Physical activity may help prevent atrophy of the hippocampus, a brain region important for learning and memory that often shrinks in the brains of people with Alzheimer’s disease. A recent study that looked at the rate of atrophy over 18 months in cognitively normal older adults suggests that physical activity may help prevent or delay this Alzheimer’s-related change.

Blog post - Alzheimer’s disease research & the U.S. NIH: what’s new?

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International collaboration is vital to advancing Alzheimer’s disease research, from genetics to biomarkers to translational research.

Blog post - new funding for health disparities research

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New funding for health disparities research has just been announced by the National Institute on Aging. This funding will add health disparities projects and researchers to existing NIA grants. Grad students, postdocs, and junior faculty members with appropriate, rigorous projects can work with funded investigators to take advantage of this research funding opportunity.

Blog post - women of color and career advancement

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Women of color continue to face many challenges in science. Too often, they experience covert or overt racism and sexism in science classrooms and in research workplaces. In a new blog post, Marie Bernard, Deputy Director at the National Institute on Aging, relates how her own experiences encouraged her to get involved in the Women of Color Research Network at NIH.

Blog post - Go4Life, the NIA health education campaign

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Research shows that older adults who are active have a lower risk of diabetes, hypertension, coronary heart disease, obesity, depression, and some cancers than their less fit peers.

Landmark A4 Alzheimer's prevention trial now enrolling

A4 study logo -- 'The A4 Study' Healthy older adults age 65 to 85 with normal memory but who may be at risk of Alzheimer’s are invited to participate in a major clinical trial to prevent or delay the disease.

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