Heath and Aging

Biology of Aging


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Bartke, A., “The Somatotropic Axis and Aging: Mechanisms and Persistent Questions about Practical Implications,” Experimental Gerontology, 44(6-7): 372-374, 2009.

Barzilai, N. and Bartke, A., “Biological Approaches to Mechanistically Understand the Healthy Life Span Exten­sion Achieved by Calorie Restriction and Modulation of Hormones,” Journal of Gerontology: Biological Sciences, 64A(2): 187-191, 2009.

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Blagozklonny, M.V. and Campisi, J., “Cancer and Aging,” Cell Cycle, 7(17): 2615-2618, 2008.

Buffenstein, R., “The Naked Mole-Rat: A New Long-Living Model for Human Aging Research,” Journal of Gerontology: Biological Sciences, 60A(11): 1369-1377, 2005.

Calvanese, V., Lara, E., Kahn, A., and Fraga, M.F., “The Role of Epigenetics in Aging and Age-Related Diseases,” Ageing Research Reviews, 8: 268-276, 2009.

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Chen, W.H., Kozlovsky, B.F., Effros, R.B., et al., “Vaccination in the Elderly: An Immunological Perspective,” Trends in Immunology, 30(7): 351-359, 2009.

Christensen, K., Doblhammer, G., Rau, R., and Vaupel, J.W., “Ageing Populations: The Challenges Ahead,” Lancet, 374: 1196-1208, 2009.

Christensen, K., McGue, M., Petersen, I., et al., “Exceptional Longevity Does Not Result in Excessive Levels of Disability,” Proceedings of the National Academy of Sciences, 105(36): 13274-13279, 2008.

Colman, R.J., Anderson, R.M., Johnson, S.C., et al., “Calorie Restriction Delays Disease Onset and Mortality in Rhesus Monkeys,” Science, 325: 201-204, 2009.

Cox, L.S. and Mattison, J.A., “Increasing Longevity through Caloric Restriction or Rapamycin Feeding in Mammals: Common Mechanisms for Common Outcomes?” Aging Cell, 8: 607-613, 2009.

Cuervo, A.M., “Autophagy and Aging: Keeping That Old Broom Working,” Trends in Genetics, 24(12): 604-612, 2008.

Cuervo, A.M., “Calorie Restriction and Aging: The Ultimate ‘Cleansing Diet,’” Journal of Gerontology: Biological Sciences, 63A(6): 547-549, 2008.

DiCarlo, A.L., Fuldner, R., Kaminski, J., and Hodes, R., “Aging in the Context of Immunological Architecture, Function and Disease Outcomes,” Trends in Immunology, 30(7): 293-294, 2009.

Finch, C.E., “Update on Slow Aging and Negligible Senes­cence—A Mini-Review,” Gerontology, 55: 307-313, 2009.

Fraga, M.F., Ballestar, E., Paz, M.F., et al., “Epigenetic Differ­ences Arise During the Lifetime of Monozygotic Twins,” Proceedings of the National Academy of Sciences, 102(30): 10604-10609, 2005.

Garinis, G.A., van der Horst, G.T.J., Vijg, J., and Hoeijmakers, J.H.J., “DNA Damage and Ageing: New-Age Ideas for an Age-Old Problem,” Nature Cell Biology, 10(11): 1241-1247, 2008.

Geiger, H. and Rudolph, K.L., “Aging in the Lympho-hema­topoietic Stem Cell Compartment,” Trends in Immunology, 30(7): 360-365, 2009.

Globerson, A. and Barzilai, N., “The Voyage to Healthy Longevity: From Experimental Models to the Ultimate Goal,” Mechanisms of Ageing and Development, 126: 225-229, 2005.

Guarente, L., “Sirtuins in Aging and Disease,” Cold Spring Harbor Symposia on Quantitative Biology, 72: 483-488, 2007.

Guevara-Aguirre, J., Balasubramanian, P., Guevara-Aguirre, M., et al., “Growth Hormone Receptor Deficiency Is Associ­ated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans,” Science Translational Medicine, 3(70): 70ra13, 2011.

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Harrison, D.E., Strong, R., Sharp, Z.D., et al., “Rapamycin Fed Late in Life Extends Lifespan in Genetically Heteroge­neous Mice,” Nature, 460: 392-395, 2009.

Herbig, U., Ferriera, M., Condel, L., et al., “CellularSenescence in Aging Primates,” Science, 311: 1257, 2006.

Hildt, E., “Living Longer: Age Retardation and Autonomy,” Medicine, Health Care, and Philosophy, 12(2): 179-185, 2009.

Kennedy, B.K., “The Genetics of Ageing: Insight from Genome-Wide Approaches in Invertebrate Model Organ­isms,” Journal of Internal Medicine, 263: 142-152, 2008.

Khrapko, K. and Vijg, J., “Mitochondrial DNA Mutations and Aging: Devils in the Details?” Trends in Genetics, 25(2): 91-98, 2009.

Kirkwood, T.B.L., “Understanding the Odd Science of Aging,” Cell, 120: 437-447, 2005.

Leslie, M., “Searching for the Secrets of the Super Old,” Science, 321: 1764-1765, 2008.

Martin, G.M., Bergman, A., and Barzilai, N., “Genetic Deter­minants of Human Health Span and Life Span: Progress and New Opportunities,” PLoS Genetics, 3(7): 1121-1130, 2007.

Mattison, J.A., Roth, G.S., Lane, M.A., and Ingram, D.K., “Dietary Restriction in Aging Nonhuman Primates” in Mobbs, C.V., Yen, K., Hof, P.R. (eds): Mechanisms of Dietary Restriction in Aging and Disease. Interdisciplinary Topics in Gerontology. Basel, Karger, 35: 137-158, 2007.

Mattson, M., “Dietary Factors, Hormesis and Health,” Ageing Research Reviews, 7: 43-48, 2008.

Mattson, M., “Energy Intake, Meal Frequency, and Health: A Neurobiological Perspective,” Annual Review of Nutrition, 25: 237-260, 2005.

Maue, A.C., Yager, E.J., Swain, S.L., et al., “T cell Immuno-senescence: Lessons Learned from Mouse Models of Aging,” Trends in Immunology, 30(7): 301-305, 2009.

McElhaney, J.E. and Effros, R.B., “Immunosenescence: What Does It Mean to Health Outcomes in Older Adults?” Current Opinion in Immunology, 21: 418-424, 2009.

Melzer, D., “Genetic Polymorphisms and Human Aging: Association Studies Deliver,” Rejuvenation Research, 11(2): 523-526, 2008.

Michan, S. and Sinclair, D., “Sirtuins in Mammals: Insights into Their Biological Function,” Biochemical Journal, 404: 1-13, 2007.

Narasimhan, S.D., Yen, K., and Tissenbaum, H.A., “Converg­ing Pathways in Lifespan Regulation,” Current Biology, 19(15): 657-666, 2009.

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Panda, A., Arjona, A., Sapey, E., et al., “Human Innate Immu­nosenscence: Causes and Consequences for Immunity in Old Age,” Trends in Immunology, 30(7): 325-333, 2009.

Pawlikowska, L., Hu, D., Huntsman, S., et al., “Association of Common Genetic Variation in the Insulin/IGF-1 Signaling Pathway with Human Longevity,” Aging Cell, 8: 260-472, 2009.

Pearson, K.J., Baur, J.A., Lewis, K.N., et al., “Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span,” Cell Metabolism, 8: 157-168, 2008.

Pedersen, P.L., “Mitochondrial Matters of the Heart: A Plethora of Regulatory Modes to Maintain Function for a Long Lifetime,” Journal of Bioenergetics and Biomembranes, 41: 95-98, 2009.

Pérez, V.I., Buffenstein, R., Masamsetti V., et al., “Protein Sta­bility and Resistance to Oxidative Stress Are Determinants of Longevity in the Longest-Living Rodent, the Naked Mole Rat,” Proceedings of the National Academy of Sciences, 106: 3059-3064, 2009.

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Perls, T., Kunkel, L., and Puca, A., “The Genetics of Aging,” Current Opinion in Genetics & Development, 12: 362-369, 2002.

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Reddien, P.W., Bermange, A.L., Murfitt, K.J., et al., “Identifica­tion of Genes Needed for Regeneration, Stem Cell Function, and Tissue Homeostasis by Systematic Gene Perturbation in Planaria,” Developmental Cell, 8: 635-649, 2005.

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Sierra, F., “Biology of Aging Summit Report,” Journal of Gerontology: Biological Sciences, 64A(2): 155-156, 2009.

Sierra, F., Hadley, E., Suzman, R., and Hodes, R., “Prospects for Life Span Extension,” Annual Review of Medicine, 60: 457-469, 2009.

Stanfel, M.N., Shamieh, L.S., Kaeberlein, M., and Kennedy, B.K., “The TOR Pathway Comes of Age,” Biochimica et Biophysica Acta, 1790: 1067-1074, 2009.

Strong, R., Miller, R.A., Astle, C.M., et al., “Nordihydroguari­arietic Acid and Aspirin Increase Lifespan of Genetically Heterogeneous Male Mice,” Aging Cell, 7: 641-650, 2008.

Swain, S.L. and Nikolich-Zugich, J., “Key Research Opportu­nities in Immune System Aging,” Journal of Gerontology: Biological Sciences, 64A(2): 183-186, 2009.

Terry, D.F., Nolan, V.G., Andersen, S.L., et al., “Association of Longer Telomeres With Better Health in Centenarians,” Journal of Gerontology: Biological Sciences, 63A(8): 809-812, 2008.

Tower, J., “Hsps and Aging,” Trends in Endocrinology and Metabolism, 20(5): 216-222, 2009.

Vijg, J. and Campisi, J., “Puzzles, Promises and a Cure for Aging,” Nature, 454(7208): 1065-1071, 2008.

Willer, C.J., Sanna, S., Jackson, A.U., et al., “Newly Identified Loci that Influence Lipid Concentrations and Risk of Coronary Artery Disease,” Nature Genetics, 40(2): 161-169, 2008.

Publication Date: December 2011
Page Last Updated: January 25, 2012