Heath and Aging

Aging Hearts and Arteries: A Scientific Quest

Acknowledgements

Writer
Doug Dollemore
Office of Communications and Public Liaison
National Institute on Aging
National Institutes of Health

Design
Megan Riordan, Designer
John Vance, Managing Art Director
Levine & Associates, Inc.
Washington, DC

Photography/Illustrations
Cover — illustration, Levine & Associates, photos courtesy of Getty Images, Inc.

Page 2 — Three generations, illustration, Levine & Associates, photo courtesy of Getty Images, Inc.

Page 5 —"Anatomy of the Heart" illustration, Levine & Associates

Page 7 — Heart woodcut, courtesy of the National Library of Medicine, National Institutes of Health; MRI image, courtesy of Dynamic Graphics, Inc.

Page 8 — John Bicknell, illustration, Levine & Associates, photo courtesy of Doug Dollemore

Page 9 — John Bicknell photo, courtesy of Doug Dollemore

Page 10 — Edward Lakatta photo, courtesy of Edward Lakatta

Page 11 — "Heart Dynamics" illustration, Levine & Associates

Page 12 — Gary Gerstenblith photo, courtesy of Gary Gerstenblith

Page 12-13 — "In a Heart Beat" illustrations, Levine & Associates

Page 14 — PET/CT scan images of resting and stressed heart, courtesy of Swiss National Science Foundation, University Hospital, Zurich

Page 15 — "The Heart: Young and Old" illustration, Levine & Associates

Page 17 — Water aerobics photos, courtesy of the National Institute on Aging, National Institutes of Health

Page 18 — "When the Brain Talks to the Heart" illustration, Levine & Associates

Page 20 — Scientist at microscope, illustration, Levine & Associates, photo courtesy of Getty Images, Inc.

Page 21 — Myocyte, courtesy of Edward Lakatta

Page 22 — Calcium release in myocyte images, courtesy of the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia

Page 23 — "How a Myocyte Contracts" illustration, Levine & Associates

Page 27 — "Contractile Proteins" illustration, Levine & Associates

Page 28 — "Opposing Pressures" illustration, Levine & Associates

Page 29 — Christiaan Leewenburgh photo, courtesy of Christiaan Leewenburgh

Page 30 — Piero Anversa photo, courtesy of Piero Anversa

Page 31 — Stem cell, courtesy of Piero Anversa

Page 32 — Happy couple, illustration, Levine & Associates, photo courtesy of Getty Images, Inc.

Page 33 — Heart blood vessel photo, courtesy of the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia

Page 35 — Inflammation in the atherosclerosis process illustrations, courtesy of the Massachusetts Medical Society, The New England Journal of Medicine

Page 36 — "Age and Arteries" illustration, Levine & Associates

Page 37 — Magnified arterial wall section, courtesy of the University of Western Australia

Page 39 — Man getting blood pressure checked, courtesy of the National Institute on Aging, National Institutes of Health

Page 40 — "Production of Nitric Oxide" illustration, Levine & Associates

Page 41 — "Young and Old Arteries" illustration, Levine & Associates

Page 43 — DNA, courtesy of Getty Images, Inc.

Page 44 — C-reactive protein structure, adapted from original by Paul Ridker, Harvard University Medical School, Pathology Department

Page 46 — Endothelial cell, courtesy of Molecular Expressions: http://www.microscopy.fsu.edu, Florida State University

Page 47 — Exercise, courtesy of the National Institute on Aging, National Institutes of Health

Page 48 — Metabolic syndrome graph, Levine & Associates; Angelo Scuteri photo, courtesy of Angelo Scuteri

Page 49 — Man in kitchen, courtesy of Dynamic Graphics, Inc.

Page 50 — Crystallized cholesterol under the microscope, courtesy of Molecular Expressions: http://www.microscopy.fsu.edu, Florida State University

Page 51 — Nutrition label, courtesy of Getty Images, Inc.

Page 52 — Heart researchers, illustration, Levine & Associates, photos courtesy of Getty Images, Inc.

Page 53 — Willem Einthoven and early electrocardiograph, circa 1907, courtesy of the Heart Rhythm Foundation

Thanks to David Burton and Nancy Clark, JBS, Inc.
Special thanks to Edward G. Lakatta, M.D., chief of the Laboratory of Cardiovascular Science at the National Institute on Aging and to Jerome Fleg, M.D., medical officer at the National Heart, Lung and Blood Institute.

Reviewed July 2014

Publication Date:
Page Last Updated: July 22, 2014