Research

Researchers find association between abnormal tau and damaged brain cell DNA

Scientists have identified a possible cellular mechanism triggered by oxidative stress and DNA damage that is linked to tau, a protein commonly seen in the brains of people with Alzheimer’s disease and certain other neurodegenerative diseases called “tauopathies.” The effect was observed in fruit fly and mouse tauopathy models and in human Alzheimer’s brains.

Study breaks blood-brain barriers to understanding Alzheimer's

A study in mice shows how a breakdown of the brain's blood vessels may amplify or cause problems associated with Alzheimer's disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and diagnoses.

NIH deposits first batch of genomic data for Alzheimer’s disease

Researchers can now freely access the first batch of genome sequence data from the Alzheimer’s Disease Sequencing Project (ADSP), the National Institutes of Health (NIH) announced today. The ADSP is one of the first projects undertaken under an intensified national program of research to prevent or effectively treat Alzheimer’s disease.

NIH-supported study identifies 11 new Alzheimer’s disease risk genes

An international group of researchers has identified 11 new genes that offer important new insights into the disease pathways involved in Alzheimer’s disease. The highly collaborative effort involved scanning the DNA of over 74,000 volunteers—the largest genetic analysis yet conducted in Alzheimer’s research—to discover new genetic risk factors linked to late-onset Alzheimer’s disease, the most common form of the disorder.

New database helps clinicians, researchers find instruments to detect cognitive impairment in older adults

Evaluating the cognitive status of older patients in the primary care setting is one of the first steps in determining the cause of problems with memory, attention, and other aspects of thinking that can affect their health and well-being. With dozens of instruments available, finding the right ones to use can be a challenge. Now, clinicians and researchers have a new and simple way to find appropriate instruments—through a searchable database from the National Institute on Aging (NIA) at the National Institutes of Health.

Falls may be sign of future Alzheimer’s disease, cognitive decline

Cognitively normal older adults with evidence of early brain changes typical of Alzheimer’s disease fell more often than did their peers without these brain changes, a new study reported online in Neurology. The results suggest that declines in mobility may precede the symptoms of cognitive decline found in Alzheimer’s disease.

Estrogen therapy has no long-term effect on cognition in younger postmenopausal women

A randomized clinical trial of estrogen therapy in younger postmenopausal women, aged 50–55, has found no long-term risk or benefit to cognitive function. The National Institutes of Health-supported study, reported in JAMA Internal Medicine on June 24, 2013, looked at women taking conjugated equine estrogens, the most common type of postmenopausal hormone therapy in the United States.

The earlier Women’s Health Initiative Memory Study (WHIMS) linked the same type of hormone therapy to cognitive decline and dementia in older postmenopausal women.

Preventing Alzheimer’s Disease

Inglés

Although Alzheimer's disease currently has no cure, recent research results point toward a day when it might be possible to delay, slow down, or even prevent this devastating brain disorder. This 24-page booklet describes the latest NIA-funded research about prevention of Alzheimer's disease and age-related cognitive decline, from physical exercise and diet to social engagement and cognitive training. Also included are tips for staying healthy as you grow older.

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