Ongoing NIA-Funded Clinical Trials

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TABLE 1. Ongoing Alzheimer's Disease Presymptomatic/Primary Prevention Trials Funded by NIA
TRIAL NAME
PRINCIPAL INVESTIGATOR/
INSTITUTION
ANTICIPATED COMPLETION DATE
Nutritional
PREADVISE (Prevention of Alzheimer's Disease by Vitamin E and Selenium)*
Frederick Schmitt, University of Kentucky
2014
AREDS2 (Age-Related Eye Disease Study 2) **
John Paul San Giovanni (Study Director), NEI
2015
Hormones
ELITE (Early Versus Late Intervention with Estradiol)
Howard Hodis, University of Southern California
2014
Lon Schneider, University of Southern California
2014
Cardiovascular
Cynthia Carlsson, University of Wisconsin, Madison
2014
Gail Li, University of Washington 2014
SPRINT-MIND (Systolic Blood Pressure Intervention Trial-MIND)*
David Reboussin, Wake Forest University
2017
ASPREE (Aspirin in Reducing Events in the Elderly)
Richard Grimm, Berman Center for Outcomes & Clinical Research; John McNeil, Monash University
2017
Immunotherapy
API ADAD (Alzheimer’s Prevention Initiative Autosomal Dominant Alzheimer’s Disease Trial)
Eric Reiman, Banner Alzheimer’s Institute
2018
API APOE4 (Alzheimer’s Prevention Initiative Apolipoprotein E4 Trial)
Eric Reiman, Banner Alzheimer’s Institute
2019
DIAN (Dominantly Inherited Alzheimer Network Trial)
Randall Bateman, Washington University
2019
A4 Trial (Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease) ***
Reisa Sperling, Harvard Medical School
2019
Nonpharmacological—Exercise
LIFE (Lifestyle Interventions and Independence for Elders)
Marco Pahor, University of Florida
2014
Jennifer Etnier, University of North Carolina at Greensboro
2018
Jeffrey Burns, University of Kansas 2019
Nonpharmacological—Other
Hiroko Dodge, Oregon Health & Science University
2014
Other Interventions
Yvette Sheline, Washington University
2018

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or www.ClinicalTrials.gov.

*NIA-funded primary prevention add-on trials: PREADVISE (add-on to National Cancer Institute's SELECT trial); SPRINT-MIND (add-on to National Heart, Lung, and Blood Institute's and National Institute of Diabetes and Digestive and Kidney Diseases' SPRINT trial; co-funded with the National Institute of Neurological Disorders and Stroke).

** Co-funded trial: AREDS2 (National Eye Institute, lead institute).

*** Trial supported through Alzheimer’s Disease Cooperative Study (ADCS).

TABLE 2. Ongoing Alzheimer’s Disease/MCI Clinical Trials Funded by NIA
TRIAL NAME
PRINCIPAL INVESTIGATOR/
INSTITUTION
ANTICIPATED COMPLETION DATE
Nutritional
Lynne Shinto, Oregon Health & Science University
2014
Cardiovascular
Giulio Maria Pasinetti, Mt. Sinai School of Medicine; Paul Rosenberg, Johns Hopkins University
2015
Ihab Hajjar, University of Southern California 2018
Hormones
Roberta Diaz Brinton, University of Southern California 2019
Metabolic
Jose Luchsinger, Columbia University 2014
Robert Schwartz, University of Colorado Denver 2014
Suzanne Craft, University of Washington 2016
Suzanne Craft, University of Washington 2018
Nonpharmacological—Exercise
Jeffrey Burns, University of Kansas 2014
Rong Zhang and Hanzhang Lu, University of Texas Southwestern 2014

Thomas Obisesan, Howard University

2014

Cay Anderson-Hanley, Union College

2019

Fang Yu, University of Minnesota 2019
Nonpharmacological—Other
Miriam Mintzer, Johns Hopkins University 2014
ADMIT (Alzheimer’s Disease Multiple Intervention Trial)
Chris Callahan, Indiana University 2016
Barry Rovner, Thomas Jefferson University 2016
Constantine Lyketsos, Johns Hopkins University
2018
Other Interventions
Paul Aisen, University of California, San Diego 2014
Marwan Sabbagh, Banner Sun Health Research Institute 2014
R. Scott Turner, Georgetown University 2017
Davangere Devanand, Columbia University 2019
Gregory Jicha, University of Kentucky 2019
Ted Ashburn, Sanofi Aventis US, Inc. 2019

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or www.ClinicalTrials.gov.

* Trial supported through Alzheimer’s Disease Cooperative Study (ADCS).

TABLE 3. Ongoing Age-Related Cognitive Decline Clinical Trials Funded by NIA
TRIAL NAME
PRINCIPAL INVESTIGATOR/
INSTITUTION
ANTICIPATED COMPLETION DATE
Cognitive Training
Mark D'Esposito, University of California, Berkeley
2012
Kristi Multhaup, Davidson College; Mark Faust, University of North Carolina Charlotte
2013
Omega-3 Fatty Acids and Antioxidants
Robert Krikorian, University of Cincinnati
2013
VITAL-Cog (A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline)
Jae Kang, Brigham and Women's Hospital
2015

Gene Bowman, Oregon Health & Science University

2018

Cardiovascular
Ihab Hajjar, University of Southern California
2012
Active Engagement
Denise Park, University of Texas, Dallas
2014
Elizabeth Stine-Morrow, University of Illinois, Urbana-Champaign
2014
Arthur Kramer, University of Illinois, Urbana-Champaign
2015
Hormones
Sanjay Asthana, University of Wisconsin, Madison
2012
Paul Newhouse, Vanderbilt University
2014
Peter Snyder, University of Pennsylvania
2015
Metabolic
CNS-Elders (Cardiac Surgery Neuroprotection Study in Elders)
Shi-jun Jean Hsieh, Albert Einstein College of Medicine, Yeshiva University
2014
Exercise
Jeffrey Burns, University of Kansas
2013
Yaakov Stern & Richard Sloan, Columbia University
2015
Scott Small & Richard Sloan, Columbia University
2015
Exercise and Cognitive Training
Yaakov Stern, Columbia University
2013
EXACT (Combining Exercise and Cognitive Training to Improve Everyday Function)
Ellen Binder & Mark McDaniel, Washington University
2013
ACE-Seniors (Activities for Cognitive Enhancement of Seniors)
Victor Henderson, Stanford University
2013
FAST (Fit & Active Seniors Trial)
Arthur Kramer, University of Illinois, Urbana-Champaign
2015
Other
Manjula Kurella Tamura, Stanford University
2012

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or ClinicalTrials.gov.

TABLE 4. Ongoing Delirium Prevention & Treatment Clinical Trials Funded by NIA
TRIAL NAME

PRINCIPAL INVESTIGATOR/
INSTITUTION

ANTICIPATED COMPLETION DATE
Jeffrey Silverstein, Mt. Sinai School of Medicine
2014
Malaz Boustani, Indiana University School of Medicine
2015
Thomas Robinson, University of Colorado, Denver
2015
STRIDE (Postoperative Delirium in Elderly Surgical Patients)
Frederick Sieber, Johns Hopkins University
2015
MIND-USA (Modifying the Impact of ICU-Associated Neurological Dysfunction-USA Study)
E. Wesley Ely, Vanderbilt University Medical Center
2016

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or ClinicalTrials.gov.

TABLE 5. Ongoing Alzheimer’s Disease/MCI Neuropsychiatric Symptom Clinical Trials Funded by NIA
TRIAL NAME
PRINCIPAL INVESTIGATOR/
INSTITUTION
ANTICIPATED COMPLETION DATE
CITAD (Citalopram Treatment for Agitation in Alzheimer Dementia)
Constantine Lyketsos, Johns Hopkins University
2014
Elaine Peskind, University of Washington
2014
Davangere Devanand, New York State Psychiatric Inst./ Columbia University
2015
Laura Gitlin, Johns Hopkins University
2018

Elizabeth Galik, University of Maryland

2019