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Send to friend- TABLE 1. Ongoing Alzheimer’s Disease/MCI Prevention Trials Funded by NIA
- TABLE 2. Ongoing Alzheimer’s Disease/MCI Treatment and Feasibility Clinical Trials Funded by NIA
- TABLE 3. Ongoing Age-Related Cognitive Decline Clinical Trials Funded by NIA
- TABLE 4. Ongoing Delirium Prevention & Treatment Clinical Trials Funded by NIA
|
TRIAL NAME
|
PRINCIPAL INVESTIGATOR/
INSTITUTION |
ANTICIPATED COMPLETION DATE
|
|---|---|---|
| Nutritional | ||
|
PREADVISE (Prevention of Alzheimer's Disease by Vitamin E and Selenium)*
|
Frederick Schmitt, University of Kentucky |
2014
|
|
AREDS2 (Age-Related Eye Disease Study 2)†
|
John Paul San Giovanni (Study Director), NEI |
2015
|
| Hormones | ||
|
ELITE (Early Versus Late Intervention with Estradiol)
|
Howard Hodis, University of Southern California |
2014
|
| Cardiovascular | ||
|
SPRINT-MIND (Systolic Blood Pressure Intervention Trial-MIND)*
|
David Reboussin, Wake Forest University |
2017
|
|
ASPREE (Aspirin in Reducing Events in the Elderly)
|
Richard Grimm, Berman Center for Outcomes & Clinical Research; John McNeil, Monash University |
2017
|
| Ihab Hajjar, University of Southern California |
2018
|
|
| Metabolic | ||
| Jose Luchsinger, Columbia University |
2012
|
|
| Robert Schwartz, University of Colorado, Denver |
2013
|
|
| Immunotherapy | ||
| Eric Reiman, Banner Alzheimer’s Institute |
2018
|
|
| Nonpharmacological | ||
| Miriam Mintzer, Johns Hopkins University |
2014
|
|
| Barry Rovner, Thomas Jefferson University |
2016
|
|
| Jennifer Etnier, University of North Carolina at Greensboro |
2018
|
|
Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or www.ClinicalTrials.gov.
*NIA-funded primary prevention add-on trials: PREADVISE (add-on to National Cancer Institute's SELECT trial); SPRINT-MIND (add-on to National Heart, Lung, and Blood Institute's and National Institute of Diabetes and Digestive and Kidney Diseases' SPRINT trial; co-funded with the National Institute of Neurological Disorders and Stroke).
† Co-funded trial: AREDS2 (National Eye Institute, lead institute).
|
TRIAL NAME
|
PRINCIPAL INVESTIGATOR/
INSTITUTION |
ANTICIPATED COMPLETION DATE
|
|
|---|---|---|---|
|
Treatment Trials—Cognition
|
|||
| Nutritional | |||
| Lynne Shinto, Oregon Health & Science University |
2014
|
||
| Nonpharmacological | |||
| Jeffrey Burns, University of Kansas |
2014
|
||
|
ADMIT (Alzheimer's Disease Multiple Intervention Trial)
|
Chris Callahan, Indiana University |
2016
|
|
| Grover Gilmore, Case Western Reserve University |
2015
|
||
| Immunotherapy | |||
|
Immune Globulin Intravenous (IGIV 10%) for the Treatment of Mild-to-Moderate Alzheimer’s Disease (passive immunization)*
|
Norman Relkin, Weill Medical College, Cornell University |
2013
|
|
| Other Interventions | |||
| Paul Aisen, University of California, San Diego |
2014
|
||
| R. Scott Turner, Georgetown University |
2017
|
||
|
Treatment Trials—Neuropsychiatric Comorbidities
|
|||
|
CITAD (Citalopram Treatment for Agitation in Alzheimer Dementia)
|
Constantine Lyketsos, Johns Hopkins University |
2014
|
|
| Davangere Devanand, New York State Psychiatric Inst./ Columbia University |
2015
|
||
| Elaine Peskind, University of Washington |
2013
|
||
| Laura Gitlin, Johns Hopkins University |
2018
|
||
|
Proof of Concept Trials
|
|||
| Cardiovascular | |||
| Gail Li, University of Washington |
2013
|
||
|
SHARP (Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer’s Disease)
|
Cynthia Carlsson, University of Wisconsin, Madison |
2013
|
|
| Giulio Maria Pasinetti, Mt. Sinai School of Medicine; Paul Rosenberg, Johns Hopkins University |
2015
|
||
| Hormones | |||
|
phytoSERM (Phytoserms for Menopause Symptoms and Age-Associated Memory Decline)
|
Lon Schneider, University of Southern California |
2014
|
|
| Metabolic | |||
| Suzanne Craft, University of Washington |
2016
|
||
| Suzanne Craft, University of Washington |
2018
|
||
| Nonpharmacological | |||
|
AETMCI (Aerobic Exercising Training in MCI)
|
Rong Zhang & Hanzhang Lu, University of Texas Southwestern Medical Center |
2014
|
|
| Thomas Obisesan, Howard University |
2014
|
||
|
LIFE (Lifestyle Interventions and Independence for Elders)
|
Marco Pahor, University of Florida |
2013
|
|
| Hiroko Dodge, Oregon Health & Science University |
2014
|
||
| Constantine Lyketsos, Johns Hopkins University |
2018
|
||
| Other Interventions | |||
| Marwan Sabbagh, Banner Sun Health Research Institute |
2014
|
||
| Yvette Sheline, Washington University |
2018
|
||
Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or www.ClinicalTrials.gov.
*Trial supported through Alzheimer’s Disease Cooperative Study (ADCS)
|
TRIAL NAME
|
PRINCIPAL INVESTIGATOR/
INSTITUTION |
ANTICIPATED COMPLETION DATE
|
|---|---|---|
| Cognitive Training | ||
| Mark D'Esposito, University of California, Berkeley |
2012
|
|
| Kristi Multhaup, Davidson College; Mark Faust, University of North Carolina Charlotte |
2013
|
|
|
IHAMS (Iowa Healthy and Active Minds Study)
|
Fredric D. Wolinsky, University of Iowa |
2011*
|
| Omega-3 Fatty Acids and Antioxidants | ||
| Robert Krikorian, University of Cincinnati |
2012
|
|
|
VITAL-Cog (A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline)
|
Jae Kang, Brigham and Women's Hospital |
2015
|
| Cardiovascular | ||
|
AVEC (Antihypertensives and Vascular, Endothelial and Cognitive Function Trial)
|
Ihab Hajjar, University of Southern California |
2012
|
| Active Engagement | ||
| Denise Park, University of Texas, Dallas |
2012
|
|
| George Rebok, Johns Hopkins University |
2011*
|
|
| Arthur Kramer, University of Illinois, Urbana-Champaign |
2015
|
|
| Elizabeth Stine-Morrow, University of Illinois, Urbana-Champaign |
2012
|
|
| Hormones | ||
| Paul Newhouse, Vanderbilt University |
2014
|
|
| Natalie Rasgon, Stanford University |
2011*
|
|
| Yolanda Smith, University of Michigan |
2011*
|
|
| Sanjay Asthana, University of Wisconsin, Madison |
2012
|
|
| Elliot Hirshman, George Washington University |
2011*
|
|
| Peter Snyder, University of Pennsylvania |
2015
|
|
| Metabolic | ||
| Shi-jun Jean Hsieh, Albert Einstein College of Medicine, Yeshiva University |
2013
|
|
| Exercise | ||
| Yaakov Stern & Richard Sloan, Columbia University |
2015
|
|
| Jeffrey Burns, University of Kansas |
2012
|
|
| Scott Small & Richard Sloan, Columbia University |
2015
|
|
| Exercise and Cognitive Training | ||
| Sandra Chapman, University of Texas, Dallas |
2011*
|
|
| Yaakov Stern, Columbia University |
2012
|
|
|
EXACT (Combining Exercise and Cognitive Training to Improve Everyday Function)
|
Ellen Binder & Mark McDaniel, Washington University |
2012
|
| Karlene Ball, University of Alabama, Birmingham |
2011*
|
|
|
FAST (Fit & Active Seniors Trial)
|
Arthur Kramer, University of Illinois, Urbana-Champaign |
2014
|
|
ACE-Seniors (Activities for Cognitive Enhancement of Seniors)
|
Victor Henderson, Stanford University |
2012
|
| Other | ||
| Christopher Van Dyck, Yale University |
2011*
|
|
| Manjula Kurella Tamura, Stanford University |
2012
|
|
Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or ClinicalTrials.gov.
*Results are pending for clinical trials completed in 2011.
|
TRIAL NAME
|
PRINCIPAL INVESTIGATOR/ |
ANTICIPATED COMPLETION DATE
|
|---|---|---|
| Delirium | ||
| Malaz Boustani, Indiana University School of Medicine |
2015
|
|
|
MIND-USA (The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA Study)
|
E. Wesley Ely, Vanderbilt University Medical Center |
2016
|
| Thomas Robinson, University of Colorado, Denver |
2015
|
|
|
STRIDE (Postoperative Delirium in Elderly Surgical Patients)
|
Frederick Sieber, Johns Hopkins University |
2015
|
| Jeffrey Silverstein, Mt. Sinai School of Medicine |
2012
|
|
Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or ClinicalTrials.gov.