Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease
Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease
Overall Status:
Recruiting
Brief Description:
The purpose of this study is to determine the eligibility of individuals for Alzheimer's disease clinical trials.
Patient Qualifications:
| Min Age | Max Age | Gender | Healthy Volunteers |
|---|---|---|---|
45 Years | N/A | Both | Accepts Healthy Volunteers |
Inclusion Criteria:
- Age 45 or older
- History of progressive memory impairment
- Caregiver who is willing to accompany the subject to the National Institutes of Health Clinical Center
Exclusion Criteria:
- Diagnosis of a non-Alzheimer's dementia, including frontotemporal dementia, normal pressure hydrocephalus, Lewy body dementia, Parkinson's disease dementia, Huntington's disease, or vascular dementia
- Pregnant women; women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test
- Any medical contraindication to the procedures performed in the study or any current severe medical or psychiatric illness other than Alzheimer's
- Behavioral symptoms that preclude the gathering of data for the study or advanced disease such that volunteers cannot provide assent
Detailed Description:
Individuals who demonstrate symptoms of Alzheimer's disease, such as progressive memory loss, may be eligible to participate in National Institutes of Health research studies. However, other physical and psychological conditions may produce symptoms similar to those of Alzheimer's. To determine whether a patient meets the eligibility criteria to participate in a research study, researchers must perform a series of diagnostic tests and procedures. These evaluations are designed to evaluate a participant's general medical condition (using, for example, blood tests and neurological exams) and to confirm a diagnosis or rule out an individual for consideration.
Required tests and procedures for various research studies may include the following: medical history and physical examination, including a psychiatric evaluation; neuropsychological tests to test memory, mood, concentration, and thought processes; blood and urine tests; and imaging studies (X-rays, magnetic resonance imaging, computerized tomography, positron emission tomography. After all eligibility assessments are complete, participants may be offered participation in one or more research protocols.
Locations:
| Map Marker | City | State | Zip Code | Status | Primary Contact | |
|---|---|---|---|---|---|---|
Geolocation is 39.0023604, -77.097455 | Bethesda | Maryland | 20892 | Recruiting | Name: Phone: |
Lead Sponsor:
| Agency |
|---|
National Institute of Mental Health (NIMH) |
Collaborator Sponsor:
Facility Investigators:
| Name | Role | Affiliation |
|---|---|---|
William C. Kreisl, MD | Principal Investigator | National Institute of Mental Health (NIMH) |
Study Contact:
| Name | Phone | |
|---|---|---|
Meghan S. McGwier | 301-451-2038 |
Locations
ClinicalTrials.gov ID
NCT00955422 (follow link to view full record on ct.gov in new window)
Official Title:
Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease
Study Start Date:
July 2009
Disease Stage:
Pre-clinical
Enrollment:
550
Trial References:
