Alzheimer's Disease Education and Referral Center

Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease

Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease

Overall Status: 
Recruiting
Brief Description: 

The purpose of this study is to determine the eligibility of individuals for Alzheimer's disease clinical trials.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
45 Years
N/A
Both
Accepts Healthy Volunteers
Inclusion Criteria: 

  • Age 45 or older
  • History of progressive memory impairment
  • Caregiver who is willing to accompany the subject to the National Institutes of Health Clinical Center

Exclusion Criteria: 

  • Diagnosis of a non-Alzheimer's dementia, including frontotemporal dementia, normal pressure hydrocephalus, Lewy body dementia, Parkinson's disease dementia, Huntington's disease, or vascular dementia
  • Pregnant women; women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test
  • Any medical contraindication to the procedures performed in the study or any current severe medical or psychiatric illness other than Alzheimer's
  • Behavioral symptoms that preclude the gathering of data for the study or advanced disease such that volunteers cannot provide assent

Detailed Description: 

Individuals who demonstrate symptoms of Alzheimer's disease, such as progressive memory loss, may be eligible to participate in National Institutes of Health research studies. However, other physical and psychological conditions may produce symptoms similar to those of Alzheimer's. To determine whether a patient meets the eligibility criteria to participate in a research study, researchers must perform a series of diagnostic tests and procedures. These evaluations are designed to evaluate a participant's general medical condition (using, for example, blood tests and neurological exams) and to confirm a diagnosis or rule out an individual for consideration. 

Required tests and procedures for various research studies may include the following: medical history and physical examination, including a psychiatric evaluation; neuropsychological tests to test memory, mood, concentration, and thought processes; blood and urine tests; and imaging studies (X-rays, magnetic resonance imaging, computerized tomography, positron emission tomography. After all eligibility assessments are complete, participants may be offered participation in one or more research protocols.

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 39.0023604, -77.097455

Site
Bethesda
Maryland
20892
Recruiting
Name: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
Phone: 800-411-1222
Email: prpl@mail.cc.nih.gov
Lead Sponsor: 
Agency
National Institute of Mental Health (NIMH)
Collaborator Sponsor: 
Facility Investigators: 
NameRoleAffiliation
William C. Kreisl, MD
Principal Investigator
National Institute of Mental Health (NIMH)
Study Contact: 
NamePhoneEmail
Meghan S. McGwier
301-451-2038
Locations
 
 
ClinicalTrials.gov ID 
NCT00955422 (follow link to view full record on ct.gov in new window)
Official Title: 
Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease
Study Start Date: 
July 2009
Disease Stage: 
Pre-clinical
Enrollment: 
550