Retaining Cognition While Avoiding Late-Life Depression (RECALL)
Retaining Cognition While Avoiding Late-Life Depression (RECALL)
Overall Status:
Recruiting
Brief Description:
This study will adapt and test Problem Solving Therapy (PST) as a way to prevent major depression in older adults with mild cognitive impairment (MCI). The study will also examine the effect of exercise on preventing depression.
Patient Qualifications:
| Min Age | Max Age | Gender | Healthy Volunteers |
|---|---|---|---|
60 Years | N/A | Both | No |
Inclusion Criteria:
- Diagnosis of MCI
- Modified Mini Mental State Examination score of 80 or higher
- Adequate physical and sensory function to undergo neuropsychiatric assessment
- PHQ-9 score of 1-9, with at least one of the cardinal symptoms of depression
Exclusion Criteria:
- Major depressive episode or anxiety disorder within the past year; currently taking an antidepressant
- History of bipolar disorder or schizophrenia
- Drug or alcohol use disorder within the past 12 months
- Currently taking anti-anxiety medication more than four times per week for the past 4 weeks
- Availability of a support person
Detailed Description:
This study is for adults age 60 and older who have noticed mild memory changes in themselves or a loved one. Mild memory changes may feel stressful and increase an individual's risk of developing depression. In this project, researchers will test whether Problem Solving Therapy (PST) can prevent major depression in people with MCI. The effect of modest exercise on mood will also be investigated. Participants will take part in 8 to 12 PST sessions during 16 weeks. All treatments are provided at no cost, and participants will be paid.
Locations:
| Map Marker | City | State | Zip Code | Status | Primary Contact | |
|---|---|---|---|---|---|---|
Geolocation is 40.4379259, -79.9556424 | Univ. of Pittsburgh Medical Center Western Psychiatric Institute and Clinic | Pittsburgh | Pennsylvania | 15213 | Recruiting | |
Geolocation is 40.4379259, -79.9556424 | Univ. of Pittsburgh Medical Center Late-Life Evaluation and Treatment Center | Pittsburgh | Pennsylvania | 15213 | Recruiting |
Lead Sponsor:
| Agency |
|---|
National Institute of Mental Health (NIMH) |
Collaborator Sponsor:
Facility Investigators:
| Name | Role | Affiliation |
|---|---|---|
Meryl Butters, MD | Principal Investigator | University of Pittsburgh |
Ariel Gildengers, MD | Principal Investigator | University of Pittsburgh |
Study Contact:
| Name | Phone | |
|---|---|---|
Michelle Zmuda | 412-246-4687 |
Locations
ClinicalTrials.gov ID
NCT01886586 (follow link to view full record on ct.gov in new window)
Official Title:
RECALL: Retaining Cognition While Avoiding Late-Life Depression
Study Start Date:
July 2011
Study End Date:
July 2016
Disease Stage:
Early
Enrollment:
136
