Alzheimer's Disease Education and Referral Center

Retaining Cognition While Avoiding Late-Life Depression (RECALL)

Retaining Cognition While Avoiding Late-Life Depression (RECALL)

Overall Status: 
Recruiting
Brief Description: 

This study will adapt and test Problem Solving Therapy (PST) as a way to prevent major depression in older adults with mild cognitive impairment (MCI). The study will also examine the effect of exercise on preventing depression.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
60 Years
N/A
Both
No
Inclusion Criteria: 
    • Diagnosis of MCI
    • Modified Mini Mental State Examination score of 80 or higher
    • Adequate physical and sensory function to undergo neuropsychiatric assessment
    • PHQ-9 score of 1-9, with at least one of the cardinal symptoms of depression
Exclusion Criteria: 
    • Major depressive episode or anxiety disorder within the past year; currently taking an antidepressant
    • History of bipolar disorder or schizophrenia
    • Drug or alcohol use disorder within the past 12 months
    • Currently taking anti-anxiety medication more than four times per week for the past 4 weeks
    • Availability of a support person
Detailed Description: 

This study is for adults age 60 and older who have noticed mild memory changes in themselves or a loved one. Mild memory changes may feel stressful and increase an individual's risk of developing depression. In this project, researchers will test whether Problem Solving Therapy (PST) can prevent major depression in people with MCI. The effect of modest exercise on mood will also be investigated. Participants will take part in 8 to 12 PST sessions during 16 weeks. All treatments are provided at no cost, and participants will be paid.

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 40.4379259, -79.9556424

Site
Pittsburgh
Pennsylvania
15213
Recruiting
Name: Meryl Butters, MS
Phone: 412-246-5280
Email: buttersma@upmc.edu

Geolocation is 40.4379259, -79.9556424

Site
Pittsburgh
Pennsylvania
15213
Recruiting
Name: Jacqueline Stack, MSN, APRN
Phone: 412-246-6006
Email: stackja@upmc.edu
Lead Sponsor: 
Agency
National Institute of Mental Health (NIMH)
Collaborator Sponsor: 
Facility Investigators: 
NameRoleAffiliation
Meryl Butters, MD
Principal Investigator
University of Pittsburgh
Ariel Gildengers, MD
Principal Investigator
University of Pittsburgh
Study Contact: 
NamePhoneEmail
Michelle Zmuda
412-246-4687
Locations
 
 
ClinicalTrials.gov ID 
NCT01886586 (follow link to view full record on ct.gov in new window)
Official Title: 
RECALL: Retaining Cognition While Avoiding Late-Life Depression
Study Start Date: 
July 2011
Study End Date: 
July 2016
Disease Stage: 
Early
Enrollment: 
136