Purpose: To evaluate the safety of deep brain stimulation of the fornix (DBS-f) in people with mild Alzheimer's disease.
Purpose: To determine the value of arterial spin labeling magnetic resonance imaging, a measure of blood flow to the brain, in finding the cause of cognitive decline in people with mild cognitive impairment.
Purpose: To examine whether the potential benefits of low-dose aspirin outweigh the risks in people over age 70.
Purpose: To determine the effectiveness of the experimental drug BAN2401 as a possible treatment for people with mild cognitive impairment or mild Alzheimer's disease.
Purpose: To standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.
Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Purpose: To determine the study design and methods for a full-scale clinical trial that will determine whether treatment of obstructive sleep apnea in older adults with mild cognitive impairment delays cognitive decline and preserves everyday function.
Purpose: To assess the efficacy and safety of MK-8931 as a possible treatment for Alzheimer's disease.
Purpose: To determine whether increasing participation in cognitive, physical, and/or social activities prevents cognitive decline in older African Americans with mild cognitive impairment (MCI).
Problem: To test Problem Solving Therapy as a way to prevent major depression in people with mild cognitive impairment.
Purpose: To evaluate the efficacy and safety of RO4602522 in people with moderate-stage Alzheimer disease who take donepezil or rivastigmine.
Purpose: To determine whether intensive blood pressure lowering will reduce the incidence of all-cause dementia, reduce the decline of global cognitive function in key specific domains, and show changes in brain structure.
Purpose: To determine the safety and efficacy of the experimental drug TRx0237 to treat people with mild to moderate Alzheimer's disease.