Alzheimer's Disease Education and Referral Center

Search for Clinical Trials

Your Search for state of North Carolina Identified 15 Trial(s):

  • 1. AC-1204 for Mild to Moderate Alzheimer's Disease

    Purpose: To evaluate the effects of AC-1204 on cognition, activities of daily living, quality of life, pharmacokinetic measures, and safety in people with mild to moderate Alzheimer's disease.

  • 2. Aspirin in Reducing Events in the Elderly (ASPREE)

    Purpose: To examine whether the potential benefits of low-dose aspirin outweigh the risks in people over age 70.

  • 3. AVP-923 for Treatment of Agitation in Alzheimer's Patients

    Purpose: To evaluate the safety, tolerability, and efficacy of AVP-923 (dxtromethorphan/qinidine) for the treatment of agitation in people with Alzheimer's disease.

  • 4. Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Other Dementias

    Purpose: To define a biomarker using proteins found in cerebrospinal fluid to distinguish people with mild to moderate Alzheimer's disease from healthy, elderly people.

  • 5. Clinical Evaluation of Florbetapir F 18 (18F-AV-45)

    Purpose: To standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.

  • 6. COGNISION™ as a Useful Cognitive Biomarker for Alzheimer's Disease

    Purpose: To evaluate the performance of the COGNISION™ system as a tool to assist physicians in diagnosing Alzheimer's disease in real-world clinical settings.

  • 7. Combination Treatment Study for Memory Impairment and Depression

    Purpose: To determine the response of older adults with both depression and cognitive impairment to donepezil vs. placebo after treatment with antidepressants. The goal is improve cognition and delay conversion to dementia.

  • 8. ELND005 for Agitation and Aggression in Alzheimer's Disease

    Purpose: To determine whether ELND005 is effective in treating symptoms of agitation and aggression in people with Alzheimer's disease.

  • 9. Gantenerumab for Prodromal Alzheimer's Disease

    Purpose: To evaluate the safety and efficacy of the experimental drug gantenerumab on cognition and functioning in people with prodromal (very early stage) Alzheimer's disease.

  • 10. Goals of Care: A Nursing Home Trial of Decision Support for Advanced Dementia

    Purpose: To examine whether decision support for goals of care can improve the quality of communication, decision-making, and palliative care for nursing home residents with advanced dementia.

  • 11. Metabolic Cerebral Imaging in Incipient Dementia (MCI-ID)

    Purpose: To determine whether positron emission tomography (PET) scanning can help distinguish patients with early Alzheimer's changes in their brains from those having other causes of cognitive impairment more accurately than current clinical practices.

  • 12. MK-8931 for Mild to Moderate Alzheimer's Disease

    Purpose: To assess the efficacy and safety of MK-8931 as a possible treatment for Alzheimer's disease.

  • 13. RG1662 in Individuals with Down Syndrome

    Purpose: To assess the safety and tolerability of RG1662 in individuals with Down syndrome.

  • 14. RO4602522 in Patients with Moderate Alzheimer Disease on Donepezil or Rivastigmine Therapy

    Purpose: To evaluate the efficacy and safety of RO4602522 in people with moderate-stage Alzheimer disease who take donepezil or rivastigmine.

  • 15. Systolic Blood Pressure Intervention Trial: Memory and Cognition in Decreased Hypertension (SPRINT-MIND)

    Purpose: To determine whether intensive blood pressure lowering will reduce the incidence of all-cause dementia, reduce the decline of global cognitive function in key specific domains, and show changes in brain structure.

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