Search for Clinical Trials

Purpose: To identify the best methods for tracking and analyzing progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) over time.

Purpose: To evaluate the effects of AC-1204 on cognition, activities of daily living, quality of life, pharmacokinetic measures, and safety in people with mild to moderate Alzheimer's disease.

Purpose: To evaluate the safety of deep brain stimulation of the fornix (DBS-f) in people with mild Alzheimer's disease.

Purpose: To test aerobic exercise as a possible treatment for people with early-stage Alzheimer's disease.

Purpose: To find out whether regulation of brain blood flow is altered in patents with mild cognitive impairment (MCI) when compared with healthy elderly individuals and to determine whether exercise training improves brain blood flow and brain function in patients with MCI.

Purpose: To identify the genes that are responsible for causing Alzheimer's disease by collecting genetic material from families with multiple members diagnosed with Alzheimer's disease.

Purpose: To improve functioning among older adults with Alzheimer's disease by comparing a control group receiving best practices primary care with an intervention group receiving best practice primary care plus a home-based occupational therapy intervention.

Purpose: To determine the value of arterial spin labeling magnetic resonance imaging, a measure of blood flow to the brain, in finding the cause of cognitive decline in people with mild cognitive impairment.

Purpose: To examine whether the potential benefits of low-dose aspirin outweigh the risks in people over age 70.

Purpose: To evaluate the safety, tolerability, and efficacy of AVP-923 (dxtromethorphan/qinidine) for the treatment of agitation in people with Alzheimer's disease.

Purpose: To test the safety and efficacy of AZD3293 as a possible treatment for Alzheimer's disease.

Purpose: To test the efficacy, safety, and tolerability of the experimental drug AZD3480 in people with mild to moderate Alzheimer's disease.

Purpose: To determine the effectiveness of the experimental drug BAN2401 as a possible treatment for people with mild cognitive impairment or mild Alzheimer's disease.

Purpose: To determine the safety and effect on the brain of the drug bexarotene as a possible treatment for Alzheimer's disease.

Purpose: To evaluate the safety and tolerability of BIIB037 in people with prodromal or mild Alzheimer's disease.

Purpose: To study the relationship between brain MRI results and cognitive impairment in older adults with heart failure.

Purpose: To test psycho-education and physical exercise, individually and in combination, as ways to promote physical health and emotional well-being in family caregivers of people with chronic illness.

Purpose: To determine whether carvedilol treatment is associated with improvement in Alzheimer's disease (AD) compared to a placebo.

Purpose: To determine if cataract removal will improve the quality of life, vision, and cognition in people with Alzheimer's disease.

Purpose: To define a biomarker using proteins found in cerebrospinal fluid to distinguish people with mild to moderate Alzheimer's disease from healthy, elderly people.

Purpose: To standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.

Purpose: To determine the efficacy of coconut oil as a possible treatment for mild to moderate Alzheimer's disease.

Purpose: To evaluate the performance of the COGNISION™ system as a tool to assist physicians in diagnosing Alzheimer's disease in real-world clinical settings.

Purpose: To test the hypothesis that aerobic exercise leads to improved cognitive function.

Purpose: To determine the response of older adults with both depression and cognitive impairment to donepezil vs. placebo after treatment with antidepressants. The goal is improve cognition and delay conversion to dementia.

Purpose: To compare the effectiveness of approved medications for treating Alzheimer's disease in participants from real-world memory care clinics.

Purpose: To use a functional MRI (fMRI) index to compare the brain activity of healthy volunteers to that of people with mild cognitive impairment (MCI) and people with Alzheimer's disease in order to develop an early diagnostic tool for Alzheimer's.

Purpose: To examine whether conversation-based cognitive stimulation has positive effects on cognitive functions among the elderly.

Purpose:  To explore whether dietary supplementation with Anatabloc® exerts an effect on blood levels of amyloid beta (Aβ) or impacts global or functional measures of Alzheimer's disease.

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Purpose: To assess the safety, tolerability, and biomarker efficacy of gantenerumab and solanezumab in individuals who have a genetic mutation for autosomal-dominant Alzheimer's disease.

Purpose: To test the experimental drug E2609 as a possible treatment for mild cognitive impairment or mild dementia due to Alzheimer's disease.

Purpose: To determine the impact of an educational video for professional caregivers on the care of nursing homes residents with advanced dementia compared with the usual care.

Purpose: To evaluate the safety and effects of the experimental drug BMS-241027 on levels of the protein tau in cerebrospinal fluid and results of magnetic resonance imaging and cognitive tests in people with mild Alzheimer's disease.

Purpose: To examine the impact of aging on functional changes induced by estrogen in parts of the brain associated with memory

Purpose: To find out if atomoxetine causes a change in the biomarkers (substances that may indicate the presence of a disease) in the cerebrospinal fluid of people diagnosed with mild cognitive impairment.

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

Purpose: To determine the safety, tolerability, pharmacokinetics, and effects of EVP-0962 on levels of amyloid in the cerebrospinal fluid of healthy people and those with mild cognitive impairment or early Alzheimer's disease.

Purpose: To determine if Fruitflow-II (a tomato extract), resveratrol (a compound found in some foods), alone or in combination, can effectively treat memory problems in older adults with memory impairment.

Purpose: To test simvastatin to see if it produces beneficial changes in Alzheimer's-related proteins found in cerebrospinal fluid.

Purpose: To determine whether ELND005 is effective in treating symptoms of agitation and aggression in people with Alzheimer's disease.

Purpose: To determine the safety and effectiveness of twice daily administration of Exendin-4 as a treatment for early-stage Alzheimer's disease or mild cognitive impairment.

Purpose: To test the hypothesis that aerobic exercise leads to increased blood volume in the brain, specifically in the dentate gyrus of the hippocampus.

Purpose: To test the effect of a combined fitness and cognitive training intervention (in the form of dancing) on executive control, memory, brain structure, and function.

Purpose: To evaluate the safety and efficacy of the experimental drug gantenerumab on cognition and functioning in people with prodromal (very early stage) Alzheimer's disease.

Purpose: To determine whether African Americans with mild Alzheimer's disease can be enrolled and retained in a 6-month aerobic exercise training study.

Purpose: To study genetic influences on dementia.

Purpose: To develop small molecule radio-labeled probes of beta-amyloid to be used with positron emission tomography (PET) for early detection and treatment monitoring of Alzheimer disease.

Purpose: To examine whether decision support for goals of care can improve the quality of communication, decision-making, and palliative care for nursing home residents with advanced dementia.

Purpose: To test the efficacy of Problem Adaptation Therapy (PATH), a home-delivered psychosocial intervention for elders with major depression, memory problems, and disability.

Purpose: To study how the brain functions when it performs explicit memory tasks and how this changes as a function of aging.

Purpose: To determine whether asymptomatic older individuals with high amyloid burden will subsequently develop cognitive impairment and eventually progress to clinical Alzheimer's disease.

Purpose: To determine whether a combined intervention of a nighttime home monitoring system and cognitive-behavioral therapy for insomnia is effective in improving sleep in dementia caregivers who arise at night.

Purpose: To examine the effect of aerobic fitness training on older adults' cognition, brain structure, and brain function.

Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

Purpose: To see if taking lipoic acid and omega-3 fatty acids can slow the Alzheimer's disease process.

Purpose: To better understand the experience of people with frontotemporal dementia and their caregivers in order to develop better therapies.

Purpose: To examine the safety and efficacy of the experimental drug LY3002813 in people with mild cognitive impairment or mild to moderate Alzheimer's disease.

Purpose: To examine if and how brain scans can predict decline in memory and executive functioning in older adults after total knee replacement surgery.

Purpose: To test the use of continuous positive airway pressure (CPAP) to reverse some or all memory deficits in people with obstructive sleep apnea.

Purpose: To determine whether positron emission tomography (PET) scanning can help distinguish patients with early Alzheimer's changes in their brains from those having other causes of cognitive impairment more accurately than current clinical practices.

Purpose: To determine the study design and methods for a full-scale clinical trial that will determine whether treatment of obstructive sleep apnea in older adults with mild cognitive impairment delays cognitive decline and preserves everyday function.

Purpose: To assess the efficacy and safety of MK-8931 as a possible treatment for Alzheimer's disease.

Purpose: To track changes over time among individuals with frontotemporal dementia (FTD) in the brain using imaging and other biomarkers and to compare the utility of different kinds of images.

Purpose: To test the safety and effectiveness of the drug Nuedexta (dextromethorphan/quinidine) as a treatment for pseudobulbar affect in people with Alzheimer's disease.

Purpose: To determine if difficulty with the sense of smell can predict conversion from mild cognitive impairment to Alzheimer's disease and track response to donepezil therapy.

Purpose: To determine the efficacy of omega-3 fatty acids and blueberry powder in improving cognition in older adults.

Purpose: To assess the safety and efficacy of the imaging agent [18F]AZD4694 in positron emission tomography (PET) in people with probable Alzheimer's disease.

Purpose: To evaluate safety and efficacy of the experimental drug PF-05212377 in people with mild to moderate Alzheimer's disease and neuropsychiatric symptoms who take donepezil.

Purpose: To develop and test the feasibility of using a specific pharmacological protocol to reduce delirium among older adults in the intensive care unit.

Purpose: To evaluate the safety and efficacy of a soy-based dietary supplement, phytoSERM, for hot flashes and age-associated memory loss.

Purpose: To study the effectiveness of prazosin treatment for people with Alzheimer's disease or a related dementia who have difficult behaviors.

Purpose: To reduce the risk of aggressive behavior in veterans with dementia through a psychosocial intervention that addresses pain, depression, lack of pleasurable activities, caregiver stress, and difficulty in caregiver-patient communication.

Purpose: To determine whether increasing participation in cognitive, physical, and/or social activities prevents cognitive decline in older African Americans with mild cognitive impairment (MCI).

Problem: To test Problem Solving Therapy as a way to prevent major depression in people with mild cognitive impairment.

Purpose: To assess the safety and tolerability of RG1662 in individuals with Down syndrome.

Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

Purpose: To evaluate the efficacy and safety of RO4602522 in people with moderate-stage Alzheimer disease who take donepezil or rivastigmine.

Purpose: To determine whether a person meets the eligibility criteria to participate in an Alzheimer's disease research study.

Purpose: To investigate the relationship between changes in the ability to manage finances and brain perfusion (blood flow in the brain) and to discover whether changes in financial capacity are better predicted by neuropsychological tests or by an experimental brain scan.

Purpose: To document the loss of sociomoral emotions (like empathy, guilt, and embarrassment) in patients with behavioral variant frontotemporal dementia.

Purpose: To determine whether intensive blood pressure lowering will reduce the incidence of all-cause dementia, reduce the decline of global cognitive function in key specific domains, and show changes in brain structure.

Purpose: To test the efficacy of the Tailored Activity Program, a patient-centric intervention designed to reduce the burden of neuropsychiatric symptoms in veterans with dementia who live at home with family caregivers.

Purpose: To determine if participation in either of two different exercise treatments will improve walking and thinking abilities in older adults.

Purpose: To determine the safety and efficacy of the experimental drug TRx0237 to treat people with mild Alzheimer's disease.

Purpose: To determine the safety and efficacy of the experimental drug TRx0237 to treat people with mild to moderate Alzheimer's disease.

Purpose: To determine the effects of cognitive remediation training and walking on cognition and gait in the elderly.