Start:
December 2016
End:
June 2026
Enrollment:
120
Mild traumatic brain injury (TBI) from explosions is a common injury of veterans, and multiple mild TBIs can lead to chronic traumatic encephalopathy (CTE) and Alzheimer's disease years later. Prazosin is a drug approved to treat several conditions, including high blood pressure and sleep problems associated with post-traumatic stress disorder. Researchers believe the drug may also be used to decrease the accumulation of proteins in the brain associated with CTE and Alzheimer's disease. This study will test prazosin in veterans who have experienced mild TBIs to explore whether it may be a possible preventive treatment. Participants will take a pill of either prazosin or a placebo three times a day for 10 weeks.
Minimum Age: 21 Years
Maximum Age: N/A
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Washington | |
---|---|
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle,
WA
98108
Recruiting
Murray A Raskind, MD |
Lead: VA Office of Research and Development
Source: ClinicalTrials.gov ID: NCT03221751
An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health