Alzheimer's Disease Education and Referral Center

Metabolic Cerebral Imaging in Incipient Dementia (MCI-ID)

Metabolic Cerebral Imaging in Incipient Dementia (MCI-ID)

Overall Status: 
Recruiting
Brief Description: 

This prospective, randomized study will examine whether positron emission tomography (PET) scanning can help distinguish patients with early Alzheimer's changes in their brains from those having other causes of cognitive impairment more accurately than current clinical practices.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
65 Years
N/A
Both
No
Inclusion Criteria: 

  • Cognitive deficit and/or personality change, observable by physician and/or close contact; in the absence of this, clear history of decline that the participant's physician deems reliable
  • If history or neurologic exam reveals suspicion of stroke, tumor, bleeding, ictal activity, or hydrocephalus, then CT/MRI and appropriate neurological or neurosurgical consultation must be obtained.
  • If present, appropriate treatment of depression, substance abuse, malnourishment, medication effects and interactions, cardiopulmonary compromise, electrolyte/calcium imbalance, anemia, hypoxemia, infection, thyroid dysfunction, renal dysfunction, hepatic dysfunction, or glucose dysregulation

Exclusion Criteria: 

  • Overt dementia with impaired ability to perform activities of daily living
  • Present or past history of thyroid disease
  • Claustrophobia, metal in body, or other condition that would preclude PET or MRI
  • Visual, auditory, or motor deficits that would preclude accurate neuropsychological testing
  • Prohibited medications: Cholinesterase inhibitors

Detailed Description: 

This study is designed to measure how knowledge of cerebral metabolic information influences the diagnosis and management of patients being evaluated for symptoms of early cognitive decline. It will also evaluate the impact on long-term clinical outcomes, particularly of subjects having metabolic patterns consistent with Alzheimer's disease-like changes in their brains.

In this prospective investigation, subjects will undergo baseline neuropsychological testing and neuroimaging with MRI and FDG PET. PET scan reports will be sealed and randomized, released to patients' managing physicians either at the time of interpretation or 2 years after scanning. Managing physicians' working diagnoses and treatment decisions will be recorded. Cognitive abilities, functional status, utilization of healthcare resources, and other clinical and social contact parameters will be assessed every 6 months.

Our major hypotheses are that among patients whose PET results are immediately conveyed to their referring physicians, diagnoses and management plans will be positively affected, leading to more effective utilization of healthcare resources and maintenance of cognitive and functional abilities at a higher level.

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 33.6923299, -111.9403254

Site
Phoenix
Arizona
85054
Recruiting
Name: Donna Stearns, RN, Coordinator
Phone: (480) 301-7570
Email: stearns.donna@mayo.edu

Geolocation is 34.0741548, -118.3724915

Site
Los Angeles
California
90048
Recruiting
Name: Grace Ih, Site Coordinator
Phone: 310-423-7546
Email: Grace.Ih@cshs.org

Geolocation is 34.070264, -118.4440562

Site
Los Angeles
California
90095-6942
Recruiting
Name: Cheri L Geist, Coordinator
Phone: 310-794-5067
Email: cgeist@mednet.ucla.edu

Geolocation is 34.02875, -118.4717975

Site
Santa Monica
California
90404
Recruiting
Name: Cheri L Geist, Coordinator
Phone: 310-794-5067
Email: CGeist@mednet.ucla.edu

Geolocation is 27.3086034, -82.5239953

Site
Sarasota
Florida
34239
Recruiting
Name: Susanne Myers, Coordinator
Phone: 941-365-6611
Email: susannemyers@gmail.com

Geolocation is 42.4883003, -71.2015991

Site
Burlington
Massachusetts
01805
Recruiting
Name: Nanette Matrullo, Coordinator
Phone: 781-744-2906
Email: nanette.matrullo@lahey.org

Geolocation is 42.9334868, -78.8439268

Site
Buffalo
New York
14214
Recruiting
Name: Deborah A Erb, Coordinator
Phone: 716-838-5889
Email: deberb@buffalo.edu

Geolocation is 32.785895, -79.9479496

Site
Charleston
South Carolina
29425
Recruiting
Name: Genny Starr, RN
Phone: 843-792-2807
Email: connlyg@musc.edu

Geolocation is 40.7834328, -111.7376178

Site
Salt Lake City
Utah
84108
Recruiting
Name: Renee Rider, Coordinator
Phone: 801-587-8120
Email: renee.rider@hsc.utah.edu
Lead Sponsor: 
Agency
University of California, Los Angeles
Collaborator Sponsor: 
Agency
Centers for Medicare and Medicaid Services
Facility Investigators: 
NameRoleAffiliation
Daniel H. Silverman, MD, PhD
Principal Investigator
University of California, Los Angeles
Study Contact: 
NamePhoneEmail
Cheri L. Geist
310-794-5067
Locations
 
 
ClinicalTrials.gov ID 
NCT00329706 (follow link to view full record on ct.gov in new window)
Official Title: 
Early and Long-Term Value of Imaging Brain Metabolism
Study Start Date: 
June 2006
Study End Date: 
January 2016
Disease Stage: 
Early
Enrollment: 
710