Start:
March 2013
End:
July 2018
Enrollment:
160
What Is This Study About?
The purpose of this study is to examine if and how brain scans can predict decline in memory and executive functioning in older adults after total knee replacement surgery.
Do I Qualify To Participate in This Study?
Must have:
- Planned total knee antroplasty in one knee or nonsurgical knee osteoarthritis
- Right-handedness
- No difficulties with Instrumental Activities of Daily Living
Must NOT have:
- Signs of dementia, based on telephone screening and baseline cognitive testing
- Underlying medical diseases likely to limit life span or confound outcome analyses, including: cancer requiring treatment in the past 5 years, serious infectious diseases, congestive heart failure, chronic hepatitis, history of organ transplantation, seizure disorders, or history of head trauma resulting in intensive care
- Current diagnosis of alcoholism, drug dependence; history of major tranquilizer use
- Neurodegenerative conditions, including: history of major stroke; exposure to toxins or neuroleptics; history of encephalitis; neurological signs of motor neuron disease, cerebellar involvement, supranuclear palsy, or significant orthostatic hypertension
- Psychiatric conditions, including: major psychiatric disorder, major depression, claustrophobia
- Nonmedical metal in body; pacemaker device
- Less than 5 years of formal education; inability to read or write
- Self-reported hearing difficulty that interferes with standardized test administration
Need Help?
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at
800-438-4380
or
email ADEAR.
Where Is This Study Located?
Collaborator Sponsor
-
National Institutes of Health (NIH)
-
National Institute of Nursing Research (NINR)
Source:
ClinicalTrials.gov ID:
NCT01786577