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Find more clinical trials

Human Brain Antioxidants During Oxidative Stress

Start: June 2013
End: July 2018
Enrollment: 86

What Is This Study About?

Antioxidants are natural substances that appear to fight damage caused by molecules called free radicals. As a person ages, free radicals can build up in nerve cells, causing damage that might contribute to Alzheimer's disease. In this study, researchers will measure concentrations of two antioxidants in the brain, ascorbate and glutathione, using a novel method.

Do I Qualify To Participate in This Study?

Minimum Age: 18 Years

Maximum Age: 89 Years

Must have:

  • Cognitively normal participants: age 18-22 and 70-89 years
  • Participants with mild to moderate Alzheimer's: age 65-89 years, Mini-Mental State Examination (MMSE) score of 18-26

Must NOT have:

All Participants

  • Claustrophobia or implanted metal devices
  • Pregnancy
  • Taking dietary supplements 5 F+V per day
  • Smoking
  • Poor health or systemic illness
  • Unstable medication usage or use of investigational drugs
  • Psychiatric disorder or depression
  • Substance abuse
  • Inability to complete cognitive tests written for English speakers
  • Inadequate vision or hearing

Cognitively Normal Participants

  • Medical history or evidence of cognitive problems or neurological problems
  • MMSE score of 26 or lower

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: University of Minnesota-Clinical and Translational Science Institute

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT01713816

alzheimers.gov

An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health