The purpose of this study is to test the hypothesis that aerobic exercise leads to increased blood volume in the brain, specifically in the dentate gyrus of the hippocampus, in a sample of young and older adults.
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The overall goal of this proposal is to use the high-resolution variant of functional magnetic resonance imaging (fMRI) to test the hypothesis that aerobic training will induce improvements in the function of a specific brain subregion, the dentate gyrus (DG), in a sample of younger (age 20-35) and older (age 50-65) adults. Participants will be assigned randomly to an active training condition or wait list control group. Investigators will use comprehensive neuropsychological testing to examine the relationship between changes in DG function and select cognitive capacities.
A range of studies have examined the dentate gyrus (DG) as the hippocampal subregion differentially targeted by the aging process. Physical exercise has been shown to improve both frontal lobe and hippocampal function. Previous studies in both humans and mice have shown that aerobic training selectively benefitted DG function. Investigators hope to show that physical exercise is an effective approach for ameliorating age-related cognitive decline.
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Geolocation is 40.8409822, -73.9447994
New York State Psychiatric Institute
Richard P. Sloan, PhD
Richard P. Sloan