This study will examine the effects of anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery. Two types of anesthesia, propofol and isoflurane, will be compared.
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In this study, researchers will compare the effects of two types of anesthesia on memory and other types of thinking during the 6 weeks after surgery in older individuals. They will also examine the impact on Alzheimer's disease biomarkers, specifically levels of the proteins tau and amyloid in cerebrospinal fluid, during the first 24 hours and 6 weeks after surgery.
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Geolocation is 36.0038131, -78.9387241
Miles Berger, MD, PhD
Duke University Medical Center, Anesthesiology Department, Neuroanesthesia Division