This clinical trial will investigate the effects of a 6-month cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease. Researchers want to determine if the intervention can slow cognitive decline.
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This randomized, controlled trial will investigate the effects of a 6-month, moderate-intensity cycling intervention on cognition and hippocampal volume in people with Alzheimer's disease with three aims:
Participants will be randomly assigned to the 6-month cycling program or a stretching/range-of-motion exercise program (20-50-minutes, 3 times a week). Participants will then be followed for another 6 months. Cognition will be assessed at baseline, 3, 6, 9, and 12 months. Hippocampal volume will be measured using magnetic resonance imaging (MRI) at baseline, 6, and 12 months. Transportation will be provided to participants for all study-related activities. Participants who cannot undergo MRI can still participate.
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Geolocation is 44.9741561, -93.2342
University of Minnesota-Clinical and Translational Science Institute
University of St. Thomas
Fang Yu, PhD