Alzheimer's Disease Education and Referral Center

Cycling Exercise for Treating Alzheimer's Disease

Cycling Exercise for Treating Alzheimer's Disease

Overall Status: 
Recruiting
Brief Description: 

This clinical trial will investigate the effects of a 6-month cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease. Researchers want to determine if the intervention can slow cognitive decline.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
66 Years
N/A
Both
No
Inclusion Criteria: 
    • Diagnosis of probable or possible Alzheimer's disease
    • Mini-Mental State Examination (MMSE) score of 15-26 inclusive; Clinical Dementia Rating score of 0.5-2
    • Community-dwelling (includes assisted living)
    • English-speaking
    • Approved to participate by primary care provider and cardiologist if there is significant cardiac history
    • Alzheimer's drugs allowable if on stable dose for at least 1 month
Exclusion Criteria: 
    • Resting heart rate of ≤50 or ≥100 beats/minute
    • Neurological or psychiatric disorder in the past 5 years
    • Alcohol or chemical dependency in the past 5 years
    • Contraindications to exercise
    • New symptoms or diseases that have not been evaluated by a health care provider, for example, hip fracture, ongoing and unplanned weight loss, severe shortness of breath, deep vein thrombosis, hernia, unhealed sores, joint swelling, pain, or trouble walking
    • Cardiac ischemia or serious arrhythmia shown by electrocardiograph during the screening exercise test
Detailed Description: 

This randomized, controlled trial will investigate the effects of a 6-month, moderate-intensity cycling intervention on cognition and hippocampal volume in people with Alzheimer's disease with three aims:

  • Determine the immediate effect of the cycling intervention on cognition in people with Alzheimer's
  • Examine if the cycling intervention slows cognitive decline in people with Alzheimer's over the course of 1 year
  • Assess the effect of aerobic exercise on hippocampal volume in people with Alzheimer's over the course of 1 year

Participants will be randomly assigned to the 6-month cycling program or a stretching/range-of-motion exercise program (20-50-minutes, 3 times a week). Participants will then be followed for another 6 months. Cognition will be assessed at baseline, 3, 6, 9, and 12 months. Hippocampal volume will be measured using magnetic resonance imaging (MRI) at baseline, 6, and 12 months. Transportation will be provided to participants for all study-related activities. Participants who cannot undergo MRI can still participate.

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 44.9741561, -93.2342

University of Minnesota
Minneapolis
Minnesota
55455
Recruiting
Mary-Elizabeth Pasquesi
612-626-9490
mpasques@umn.edu
Lead Sponsor: 
Agency
University of Minnesota-Clinical and Translational Science Institute
Collaborator Sponsor: 
Agency
Mayo Clinic
University of St. Thomas
Facility Investigators: 
NameRoleAffiliation
Fang Yu, PhD
Principal Investigator
Nursing
Study Contact: 
NamePhoneEmail
Mary-Elizabeth Pasquesi
612-626-9490
Locations
 
 
ClinicalTrials.gov ID 
NCT01954550 (follow link to view full record on ct.gov in new window)
Official Title: 
Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume Effects
Study Start Date: 
January 2014
Study End Date: 
July 2018
Disease Stage: 
Early
Middle
Enrollment: 
90