Alzheimer's Disease Education and Referral Center

Comparative Research of Alzheimer's Disease Drug (COMET-AD)

Comparative Research of Alzheimer's Disease Drug (COMET-AD)

Overall Status: 
Recruiting
Brief Description: 

This study will compare the effectiveness of approved medications for treating Alzheimer's disease in participants from real-world memory care clinics in Indiana.

 

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
65 Years
N/A
Both
No
Inclusion Criteria: 

  • Diagnosis of possible or probable Alzheimer's disease
  • Planning to initiate treatment with a cholinesterase inhibitor (donepezil, galantamine, or rivastigmine)
  • Planning to continue care at one of the study sites
  • Family caregiver willing to complete study outcome assessments
  • Access to a telephone
  • Ability to understand English-language survey instruments

Exclusion Criteria: 

  • Prior serious adverse event from the study medications

Detailed Description: 

The goal of this study is to improve the nation's capacity to conduct comparative effectiveness research (CER), which compares the benefits and harms of different interventions and strategies to prevent, diagnose, treat, and monitor health conditions in real-world settings. The Regenstrief Institute will collaborate with Indiana University's Center for Aging Research and Division of Clinical Pharmacology to compare the effectiveness of approved medications for treating Alzheimer's disease in participants from five memory care clinics in central Indiana. These drugs are donepezil, galantamine, and rivastigmine. Investigators will analyze treatment patterns and patients' clinical outcomes. 

 

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 39.9616798, -85.9406745

Touchpoint
Fishers
Indiana
46037
Not yet recruiting
Azita Chehresa, MD, PhD
317-621-4626
AChehresa@ecommunity.com

Geolocation is 39.7794767, -86.1700894

Wishard Health Services
Indianapolis
Indiana
46202
Recruiting
Malaz Boustani
317-423-5600

Geolocation is 39.8878841, -86.1853474

St. Vincent Center for Healthy Aging
Indianapolis
Indiana
46260
Not yet recruiting
Patrick Healey, MD
317-338-7780
pjhealey@stvincent.org

Geolocation is 39.7794767, -86.1700894

Methodist Center for Geriatric Medicine
Indianapolis
Indiana
46202
Recruiting
Eugene Lammers, MD
317-962-2929
elammers@clarian.org

Geolocation is 39.7794767, -86.1700894

University Clinical Neurology
Indianapolis
Indiana
46202
Recruiting
Martin Farlow, MD
317-278-0270
mfarlow@iupui.edu
Lead Sponsor: 
Agency
Regenstrief Institute, Indiana University Center for Aging Research
Collaborator Sponsor: 
Agency
Agency for Healthcare Research and Quality (AHRQ)
Facility Investigators: 
NameRoleAffiliation
Malaz Boustani, MD, MPH
Principal Investigator
Regenstrief Institute, Indiana University Center for Aging Research
Study Contact: 
NamePhoneEmail
Amie Frame, MPH
317-423-5910
Locations
 
 
ClinicalTrials.gov ID 
NCT01362686 (follow link to view full record on ct.gov in new window)
Official Title: 
Comparative Effectiveness Research Trial of Alzheimer's Disease Drug
Study Start Date: 
April 2011
Study End Date: 
September 2014
Disease Stage: 
Early
Middle
Enrollment: 
300