Alzheimer's Disease Education and Referral Center

Alzheimer's Prevention Through Exercise

Alzheimer's Prevention Through Exercise

Overall Status: 
Recruiting
Brief Description: 

The purpose of this study is to learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
65 Years
N/A
Both
No
Inclusion Criteria: 
    • Clinical Dementia Rating score of 0 (nondemented)
    • Brain scan (florbetapir PET) evidence of cerebral amyloidosis
    • Sedentary or underactive, as determined by the Telephone Assessment of Physical Activity
    • If taking medications, on stable doses for at least 30 days
    • Ability to complete the 1-year exercise intervention
Exclusion Criteria: 
    • Clinically significant major psychiatric disorder, such as major depression, or psychiatric symptoms that could impair completion of the study
    • Clinically significant systemic illness that may affect safety or completion of the study
    • History of clinically evident stroke
    • Clinically significant infection within the last 30 days
    • Active cardiac condition (such as angina, myocardial infarction, atrial fibrillation) or pulmonary condition within the past 2 years that could pose a safety risk to the participant, unless cleared for exercise by the participant's primary care physician or cardiologist
    • Uncontrolled hypertension within the last 6 months
    • History of drug or alcohol abuse within the last 2 years
    • Insulin-dependent diabetes mellitus
    • Significant pain or musculoskeletal disorder prohibiting participation in an exercise program
    • Unwillingness to undergo or contraindication to brain MRI scan
    • History within the last 5 years of cancer or primary/recurrent malignant disease, with the exception of resected localized cutaneous squamous cell carcinoma, nonmetastatic basal cell carcinoma, cervical carcinoma, or prostate cancer
Detailed Description: 

The main purpose of this study is to learn about the possible benefits of aerobic exercise in controlling or reducing the amount of amyloid in the brain of older adults at risk of developing Alzheimer's disease. Amyloid is a protein whose abnormal deposits in the brain are a hallmark of the disease. Investigators will also assess whether exercise reduces changes in brain structure that may lead to Alzheimer's and increases cognitive ability.

Participants in the intervention group will engage in aerobic exercise for 150 minutes per week (over 3 to 5 days) for 1 year. Those in the control group will be given educational materials on starting an exercise program but will receive no formal support for their exercise program.

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 39.06, -94.61

University of Kansas Medical Center
Kansas City
Kansas
66160
Recruiting
Angela Van Sciver
913-945-5029
AVANSCIVER@kumc.edu
Lead Sponsor: 
Agency
University of Kansas
Collaborator Sponsor: 
Agency
National Institute on Aging (NIA)
Facility Investigators: 
NameRoleAffiliation
Jeffrey Burns, MD
Principal Investigator
University of Kansas
Study Contact: 
NamePhoneEmail
Angela Van Sciver
913-945-5029
Locations
 
 
ClinicalTrials.gov ID 
NCT02000583 (follow link to view full record on ct.gov in new window)
Official Title: 
Effect of Aerobic Exercise on Pathophysiology of PreClinical Alzheimer's Disease
Study Start Date: 
November 2013
Study End Date: 
January 2018
Disease Stage: 
Pre-clinical
Enrollment: 
100