The purpose of this study is to find out whether brain blood flow is altered in patients with mild cognitive impairment (MCI), a condition characterized by memory problems greater than normal for one's age but otherwise good health. In addition, this study will determine whether exercise training improves brain blood flow and brain function in patients with MCI.
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Accepts Healthy Volunteers
Investigators plan to screen 144 patients with MCI and 60 control subjects in order to enroll 204 participants in this clinical trial. Participants will be required to make seven to nine visits, including an initial screening for eligibility to participate in the study. The experiments will measure brain blood flow, vascular function, and exercise capacity.
For those with MCI, the expected length of the study will be about 18 months, including all test visits and exercise training. Participation will end following completion of repeat testing after 1 year of moderate-intensity exercise training or control intervention of flexibility and balance training. For healthy controls, participation will last about 2-3 months, including all test visits.
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Geolocation is 32.8798071, -96.7547522
University of Texas Southwestern Medical Center
National Institute on Aging (NIA)
Rong Zhang, PhD