4 Repeat Tauopathy Neuroimaging Initiative
4 Repeat Tauopathy Neuroimaging Initiative
Overall Status:
Recruiting
Brief Description:
The purpose of this study is to identify the best methods for tracking and analyzing progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) over time. Researchers will evaluate several different tests, including brain imaging, eye movement, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence, in the hope that this information can be used to guide diagnosis and treatment of PSP and CBD in the future.
Patient Qualifications:
| Min Age | Max Age | Gender | Healthy Volunteers |
|---|---|---|---|
45 Years | 90 Years | Both | No |
Inclusion Criteria:
- Clinical diagnosis of PSP or CBD
- Reliable study partner who has frequent contact with participant
Exclusion Criteria:
- Significant neurological disease other than PSP or CBD
- Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin. or body
Detailed Description:
In this observational study, investigators will use several different tests to identify which ones are most useful for tracking and analyzing PSP and CBD, two serious neurological diseases. Tests to be evaluated include brain imaging, eye movement, blood and cerebrospinal fluid samples, measurements of memory and other thinking abilities, and measures of functional independence. The long-term goal is to develop biomarkers that can provide precise, direct measures of the state of the brain, which will help improve clinical trials and, ultimately, treatment for these disorders.
Locations:
| Map Marker | City | State | Zip Code | Status | Primary Contact | |
|---|---|---|---|---|---|---|
Geolocation is 37.7748363, -122.3872576 | University of California, San Francisco | San Francisco | California | 94158 | Recruiting |
Lead Sponsor:
| Agency |
|---|
University of California, San Francisco |
Collaborator Sponsor:
| Agency |
|---|
National Institutes of Health (NIH) |
National Institute on Aging (NIA) |
Facility Investigators:
| Name | Role | Affiliation |
|---|---|---|
Adam L. Boxer, MD, PhD | Principal Investigator | University of California, San Francisco |
Study Contact:
| Name | Phone | |
|---|---|---|
Lisa B. Voltarelli | 415-476-9578 |
Locations
ClinicalTrials.gov ID
NCT01804452 (follow link to view full record on ct.gov in new window)
Official Title:
Observational Longitudinal Study of Magnetic Resonance Imaging, Specimen Biomarkers, and Clinical Progression in Progressive Supranuclear Palsy and Corticobasal Degeneration
Study Start Date:
January 2011
Study End Date:
August 2015
Enrollment:
110
Trial References:
