Transgenic Models of Disease

NIA, the National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development, and the National Center for Research Resources organized this informational meeting. This meeting's goal was to discuss the potential of using nonhuman primates (NHPs) as alternatives to mouse transgenic models of neurological diseases. The meeting convened—either in person or by teleconference—NIH extramural program directors and external experts. The discussion topics included:

• Advantages and disadvantages of current transgenic mouse models of neurological disorders
• Development of transgenics in other animal species (e.g., rats or dogs)
• The possible scientific advantages and disadvantages of developing transgenic NHP models, including technology development and choice of species
• Availability and cost of NHPs
• The length of time for disease model generation
• Ethics

Contact Information

Dr. Brad Wise
301-496-9350