The Division of Neuroscience (DN), in collaboration with the Division of Geriatrics and Clinical Gerontology Program (DGCG), organized an exploratory workshop on June 12-13, 2008, in Bethesda, MD. The workshop brought together investigators from a variety of disciplines to examine current knowledge on differing vascular pathologies in the brain and how they could contribute to Alzheimer’s Disease and other dementias, and to cognitive, motor, or affective dysfunction. Important issues addressed were: impairments in cerebral blood flow autoregulation, effects of changes in the vascular wall on blood-brain barrier function, and the degree to which adverse age-related changes in the brain vasculature are unique to the brain or reflect systemic vascular pathologies. Another important set of questions related to how cardiovascular medications commonly used in older persons (such as statins, ACE-inhibitors, angiotensin receptor blockers, and other antihypertensive medications) affect brain vasculature and vascular function, and how such effects might have neurologic consequences influencing cognition, motor function, and affective state.
Dr. Creighton Phelps